In the body, the total positive charge from cations should equal the total negative charge from anions in the blood to maintain overall neutrality. Therefore, it is common practice to not use potassium when calculating the anion gap, as it usually has little effect. However, the concentration of potassium in the blood is usually much lower compared to sodium, chloride, and bicarbonate. The anion gap is calculated using the concentrations of the major anions in the blood, chloride and bicarbonate, and the major cations, sodium and potassium. The anion gap cannot be directly measured, instead, it is calculated from the results of an electrolyte panel, another type of blood test. The anion gap is a value that represents the difference between positively charged ions (cations) and negatively charged ions (anions) in the blood. This is a useful measure to diagnose diseases and disorders associated with an acid/base imbalance in the body. The anion gap is a value calculated from the results of an electrolyte blood test which informs clinicians about the balance of positively and negatively charged particles in the blood. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at that each number in parentheses is a clickable link to peer-reviewed scientific studies. Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. Any duplication or distribution of the information contained herein is strictly prohibited.SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. Links to other sites are provided for information only – they do not constitute endorsements of those other sites. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This site complies with the HONcode standard for trustworthy health information: verify here. Learn more about A.D.A.M.'s editorial policy editorial process and privacy policy. is among the first to achieve this important distinction for online health information and services. follows rigorous standards of quality and accountability. is accredited by URAC, for Health Content Provider (URAC's accreditation program is an independent audit to verify that A.D.A.M.
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